Concepts in Pharmacokinetics, Pharmacodynamics, and Drug-Drug Interactions

This book provides a structured and mechanistically grounded overview of the core principles governing pharmacokinetics (PK), pharmacodynamics (PD), and drug-drug interactions (DDI), with a particular emphasis on the biophysical underpinnings often overlooked in the literature. Unlike conventional resources that present empirical relationships without detailing the assumptions and simplifications involved, this work systematically elucidates the foundational concepts that inform model development and data interpretation across disciplines. The content is organized into four sections: biophysical fundamentals (reaction kinetics, mass transfer, and drug binding), pharmacokinetics (including data analysis and ADME processes), pharmacodynamics (receptor binding and in vivo pharmacology), and drug-drug interactions (both PK- and PD-based mechanisms). By integrating these domains within a single volume, the book facilitates a coherent understanding of their interdependencies and supports the development of more robust and transparent pharmacological models.