Experimental Models of Parkinson’s Disease

This thoroughly revised volume compiles experimental protocols for Parkinson’s disease (PD) research, ranging from in vitro systems to animal models. Beginning with biochemical experiments and cellular models of PD involving research on astrocytes, microglia, oligodendrocytes, and co-cultures with neurons, the aggregation and propagation of a-synuclein, LRRK2, GBA1, and mitochondria-related PD causative genes, the book continues by covering mouse models as well as invertebrate and simple model organisms, including yeast, C. elegans, and Drosophila, with additional coverage of cutting-edge bioinformatics approaches. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Experimental Models of Parkinson’s Disease, Second Edition serves as an ideal guide for researchers attempting to accelerate the progress of basic research in PD.