Hepatic De Novo Lipogenesis and Regulation of Metabolism

The maintenance of metabolic health requires complex regulation of metabolic processes in metabolic tissues. The coordination of this metabolic regulation involves extensive crosstalk among tissues. Signaling factors that are secreted into the circulation and impart systemic metabolic effects include molecules such as the liver secreted hepatokines and lipid mediators. Many of these factors regulate lipid metabolism, including de novo lipogenesis. For instance, monounsaturated fatty acids, such as palmitoleate and oleate, are major products of de novo lipogenesis and exert significant control over metabolic regulation. These fatty acids may circulate as free or esterified forms and subsequently influence metabolic processes in tissues distinct from the one in which they are synthesized. Examples include the effects of hepatic palmitoleate and oleate in adipose tissue and of adipose tissue-derived palmitoleate in liver . The updated edition utilizes the vast literature and ongoing research on liver function to focus on liver de novo lipogenesis and its role in systemic metabolic processes and signaling. Each chapter has been thoroughly updated for this new edition.