Autophagy: Biology and Diseases

This four-volume set explores autophagy from multiple perspectives: Basic Science, Clinical Science, Detection Methods and Protocols, and Translational Medicine. This book focuses on "Basic Science" and covers the history and current status of autophagy research, the signaling pathways regulating the process, and the biological functions of autophagy, including its role in maintaining metabolic homeostasis through the regulation of cellular energy, lipid, and protein metabolism, its cellular quality control functions, its critical role in determining cell survival, death, and fate decisions, and its dual functions in innate and adaptive immunity. The aim of publishing this book is to present cutting-edge knowledge in the field of autophagy. This book serves as a valuable reference for researchers and clinicians working on or interested in autophagy. This volume 2 focuses on the biological functions of autophagy across diverse physiological contexts. It examines autophagy’s role in energy and lipid metabolism, protein quality control, organelle renewal, aging, immunity, reproduction, and cell fate decisions, highlighting its significance in development, differentiation, and organismal homeostasis.