Fundamentals of Cancer Metabolism

This book provides an overview of how changes in cellular metabolism support cancer growth and survival. Written for researchers, clinicians, and students, this book brings together key concepts and recent advances in a rapidly evolving field. The first part introduces the main mechanisms of metabolic reprogramming in cancer. It explains how pathways such as mTORC1 signaling and p53 function are altered, and how cancer cells use processes like glycolysis, one-carbon metabolism and macropinocytosis to support their needs. Additional chapters explore the metabolism of stem cells, lipid synthesis, epigenetic regulation, and the metabolic features that enable metastasis. The second part focuses on clinical applications, discussing how metabolic differences between tumors can be targeted, highlighting therapies against mutant IDH in glioma, and reviewing the role of diet in improving cancer treatment. The final part presents the technologies used to study cancer metabolism. Topics include metabolomics, advanced PET imaging, hyperpolarized tracers, and systems biology of metabolism. This book will be a useful resource for anyone interested in the role of metabolism in cancer and how it can be targeted in modern oncology.